On 8 June 2023, REACH Annex XVII Appendix 2 and Appendix 6 were amended as per Commission Regulation (EU) 2023/1132.

Entries 28, 29 and 30 of Annex XVII prohibit the placing on the market and use, for supply to the general public, of substances that are classified as carcinogenic, mutagenic or reproductive toxicant (CMR), categories 1A or 1B, and listed in Appendices 1 to 6 to that Annex and of mixtures containing such substances above specified concentrations.

The following substances were added to Appendix 2 to reflect new classifications of substances as CMR under Regulation (EC) No 1272/2008, as amended by Commission Delegated Regulation (EU) 2022/692:

1. Divanadium pentaoxide

2. Cumene

3. 2,2-dimethylpropan-1-ol, tribromo derivative

4. Benzophenone

The following substances were added to Appendix 6:

1. Ammonium bromide

2. Dibutyltin bis(2-ethylhexanoate)

3. Dibutyltin di(acetate)

4. Tellurium

5. Tellurium dioxide

6. Barium diboron tetraoxide

7. Diethylene glycol monomethyl ether

8. 2,4,6-tri-tert-butylphenol

9. Bisphenol S

10. 2-ethylhexanoic acid and its salts

11. Pentapotassium 2,2',2",2"’,2""-(ethane-1,2-diylnitrilo) pentaacetate

12. N-carboxymethyliminobis (ethylenenitrilo)tetra (acetic acid)

13. Pentasodium(carboxylatomethyl) iminobis (ethylenenitrilo) tetraacetate

14. Perfluoroheptanoic acid

15. 6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid, sodium and tris(2-hydroxyethyl)ammonium salts

16. 6-[(C10-C13)-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid

17. 6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid

18. Theophylline

19. N-(2-nitrophenyl)phosphoric triamide

20. Isopyrazam