On 24 April 2023, ECHA’s Public Activities Coordination Tool (PACT) was updated with 148 new intentions for Assessment of regulatory needs (ARN).

In addition, the PACT was updated with the following finalised ARN:

1. Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene),hydrochloride (8CI)

2. Poly(hexamethylenbiguanid)-hydrochlorid

3. Polyhexamethylene biguanide hydrochloride

4. PHMB

5. N,N'-bis{N-[N-(4-chlorophenyl)carbamimidoyl]carbamimidoyl}hexane-1,6-bis(aminium) diundec-10-enoate

6. N,N'''-1,6-hexanediylbis[N'-cyanoguanidine]

7. Methylphosphonic acid, compound with amidinourea (1:1)

8. Metformin hydrochloride

9. D-gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)

10. Cyanoguanidine

11. Copper(2+), bis[N-[amino(imino-.kappa.N)methyl]urea-.kappa.O]-, nitrate (1:2)

12. Chlorhexidine dihydrochloride

13. Chlorhexidine di(acetate)

14. Chlorhexidine

15. Amidinourea phosphate

16. 1-o-tolylbiguanide

17. 1-carbamimidoylurea - (nitroamino)(oxo)azane oxide (1:1)

This update brought the number of PACT ARN and Hazard assessment substances to 3527.