On 13 September 2022, the International Organization of the Flavor Industry (IOFI) updated the Global Reference List (GRL). The following substances were removed:

1. 4-(2,3,6-Trimethylphenyl)but-3-en-2-one

2. 6-Methylhept-3-en-2-one

3. 2,7-Dimethylocta-5(trans),7-dieno-1,4-lactone

4. Hex-2-eno-1,4-lactone

5. 2-Decen-1,4-lactone